UCSB 2009-2010 Catalog Course Search
Search by subject area and course number. Refer to this list of subject areas and their corresponding department.
Tip: A search for the subject area, for example, querying just "HIST" (without quotes), will return all courses of the queried subject area. Searching using subject area and number, such as "HIST 17" (without quotes), would return all courses in the series; in this example that would include HIST 17A, 17AH, 17B, etc.
| Search results: |
| BMSE 1FS - Special Topics in Biochemistry and Molecular and Cellular Biology |
| (2) STAFF |
| Prerequisites: Course(s) in high school biology and/or chemistry. |
| Freshman seminar. Exploration of the biochemical basis of selected characteristics of living systems. Biological order, specificity and continuity will be considered in terms of molecular descriptions of cells and cellular processes, including metabolism, growth and development. |
| BMSE 125A - Biochemistry |
| (4) STAFF |
| Prerequisites: Successful completion of three quarters of Organic Chemistry or equivalent consent of instructor. |
| Structure and function of proteins and other macromolecules; enzymatic catalysis. |
| BMSE 125B - Biochemistry |
| (4) STAFF |
| Prerequisites: Biochemistry and Molecular Biology 125A. |
| Metabolism; metabolic regulatory mechanisms and bioenergetics. |
| BMSE 125C - Biochemistry |
| (4) STAFF |
| Prerequisites: Biochemistry and Molecular Biology 125B. |
| Structure and function of nucleic acids; biochemistry of DNA replication, RNA transcription, and translation. |
| BMSE 156A - Physical Biochemistry |
| (5) STAFF |
| Prerequisites: One year of undergraduate courses in Biochemistry, Organic Chemistry, and Physical Chemistry. |
| Isolation and structural analysis of biomolecules; hydrodynamics, spectroscopy, diffraction, scattering. |
| BMSE 186 - Colloquia in Biomedical Research |
| (1) STAFF |
| Prerequisites: MCDB 5A-AL, MCDB 5B-BL or EEMB 5B-BL, MCDB 5C-CL, or equivalent with a gradof C or better. |
| Lectures by UCSB faculty from various departments focused on their current research in a variety of biomedical disciplines. |
| BMSE 192 - Special Topics in Biochemistry and Molecular Biology |
| (1-4) STAFF |
| Prerequisites: Upper-division standing and consent of instructor. |
| Special topics of current importance in biochemistry and molecular biology.Course content will vary. Information may be obtained in the program office. |
| BMSE 198 - Readings in Biochemistry |
| (1-5) STAFF |
| Prerequisites: A major in the life or physical sciences and consent of instructor and program. Students must 1) have attained upper-division standing; 2) have a minimum 3.0 grade-point average for the preceding three quarters; and 3) have completed at least two upper-division courses in the sciences. |
| Individual courses one hour every two weeks. Special readings designed to broaden the outlook of students and to knit into a cohesive whole the basic principles underlying the major disciplines of biochemistry and molecular biology. |
| BMSE 199 - Independent Studies |
| (1-5) STAFF |
| Prerequisites: Upper-division standing; consent of instructor and department. |
| Hours and credit arranged with any member of the staff. Laboratory. |
| BMSE 201A - Protein Structure and Function |
| (2) Plaxco |
| Prerequisites: Graduate standing. |
| Traces the physical interactions by which sequence-specific polypeptides attain a unique, functional native state. Fold design, fold prediction, and protein folding kinetics are also discussed. |
| BMSE 201B - Chemistry and Structure of Nuleic Acids |
| (2) STAFF |
| Prerequisites: MCDB 108A-B-C; and, Chemistry 113A or 142A or 142B or 142C. |
| Primary, seondary, and higher-order structures of DNA and RNA, thermodynamic stability and folding, protein-nucleic acid interactions, ribozymes, applications to gene regulation, RNA world evolution. |
| BMSE 201C - Biomembrane Structure and Function |
| (2) STAFF |
| Prerequisites: Chemistry 142A-B-C or MCDB 108A-B-C, or equivalents. |
| Lipid diversity, lipid aggregates, dynamics and phase behavior of lipid aggregates, permeabilities of model and cellular bilayers, manipulation and quantification of ionic and pH gradients, related special topics in physiology such as the mechanisms of anesthesia. |
| BMSE 202 - Biomaterials and Biosurfaces |
| (3) Israelachvili |
| Prerequisites: Consent of instructor. |
| Prior biochemistry, physical chemistry, or organic chemistry. |
| Fundamentals of natural and artificial biomaterials and biosurfaces with emphasis on molecular level structure and function and the interactions of biomaterials and surfaces with the body. Design issues of grafts and biopolymers. Basic biological and biochemical systems reviewed for nonbiologists. |
| BMSE 203 - Protein Engineering and Design |
| (3) Reich, Sagermann |
| Prerequisites: Consent of instructor. |
| Rational design of protein structure, activity, and stability. Current methods and applications of protein engineering including protein evolution, unnatural amino acids, and combinatorial methods. |
| BMSE 204 - Post-translational Protein Processing |
| (4) Waite |
| Prerequisites: MCDB 108A or 218A or equivalent. |
| Structure/function relationships in interesting macromolecules isolated from marine organisms. Focus is on well-characterized pathways from horseshoe crabs, abalones, mussels, and fish as well as others. |
| BMSE 205A - Biochemical Kinetics |
| (1) Lew |
| Prerequisites: MCDB 108A-B-C, or equivalent. |
| A practical approach to purifying and working with proteins in the laboratory. Emphasis is on techniques (mainly qualitative) with a focus on modern methods used in the research literature. Students will have an intuitive sense of protein purification, manipulations, and analysis, and should be able to critically read the primary literature upon successful completion of the course. |
| BMSE 205B - Strategies in Protein Characterization |
| (1) STAFF |
| Prerequisites: A grade of B- or better in MCDB 108A or 208A, or the equivalent. |
| A presentation of traditional and state-of-the-art approaches for characterizing the primary structure of proteins and polysaccharides. Techniques to be included are amino acid analysis, mass spectrometry, gas-phase sequencing, capillary electrophoresis, and covalent modification chemistry. |
| BMSE 207 - Enzyme Mechanisms |
| (2) Reich |
| Prerequisites: Undergraduate biochemistry course (e.g., MCDB 108). |
| Chemical mechanisms of enzyme catalysis. Enzyme models and non-classical enzymes. Theory, experimental design, and data analysis. |
| BMSE 210 - Biochemistry & Molecular Biology Techniques for Physical Scientists |
| (4) Fygenson |
| Prerequisites: Graduate standing; consent of instructor. |
| An intensive laboratory course for physical science and engineering students providing background knowledge and laboratory experience in standard molecular biology and protein purification techniques, as well as techniques for characterizing purified proteins. |
| BMSE 212 - Macromolecular Folding |
| (2) STAFF |
| Prerequisites: BMB 201A-B or equivalents. |
| Course focuses on biopolymers as structurally dynamic systems. Exploration of the relationship between biopolymer sequence, the structure that these sequences encode and the kinetic mechanisms by which this structure is achieved. |
| BMSE 215 - Biophysical Thermodynamics |
| (2) Plaxco |
| Prerequisites: Undergraduate course in Physical Chemistry (e.g., Chem 113A-B-C). |
| An overview of those parts of chemical thermodynamics relevant to the study of biomolecules and biological systems. Topics include fundamental biopolymer structure formation. |
| BMSE 216A - Spectroscopy of Biological Molecules |
| (2) STAFF |
| Prerequisites: Graduate standing. |
| Introduction to the application of spectroscopic techniques to biological systems, including UV - vis, IR, CD, fluorescence, NMR and ESR. |
| BMSE 216B - Diffraction of Biological Molecules |
| (2) STAFF |
| Prerequisites: MCDB 108A-B-C; and, Chemistry 113A or 142A or 142B or 142C. |
| Single-crystal macromolecular crystallography methods; crystal growth, geometric and physical basis of diffraction, approaches to phasing and refinement. Xray and neutron solution scattering. |
| BMSE 217 - Electrostatics of Biopolymers |
| (2) Pincus |
| Prerequisites: Knowledge of elementary ideas and methods of electrostatics and statisticalmechanics. |
| Electrostatics of highly charged sufaces in contact with a polar solvent with application to biopolymers (e.g., DNA, f-actin). |
| BMSE 218X - Selected Topics in Gene Regulation and Development |
| (1-4) STAFF |
| Prerequisites: Consent of graduate advisor. |
| Selected topics in gene regulation and development as appropriate to fulfill the course requirement of graduate students in biochemistry and molecular biology. |
| BMSE 218Y - Selected Topics in Molecular and Cellular Biology |
| (1-4) STAFF |
| Prerequisites: Consent of graduate advisor. |
| Selected topics in molecular and cellular biology as appropriate to fulfillthe course requirement of graduate students in biochemistry and molecular biology and molecular, cellular, and developmental biology. |
| BMSE 218Z - Selected Topics in the Biochemistry of Nucleic Acids and Proteins |
| (1-4) STAFF |
| Prerequisites: Consent of graduate advisor. |
| Selected topics in the biochemistry of nucleic acids and proteins as appropriate to fulfill the course requirement of graduate students in biochemistry and molecular biology. |
| BMSE 220A - Chromosomes and Cell Cycle |
| (2) STAFF |
| Prerequisites: Graduate standing. |
| Structure and organization of the nucleus, Chromatin and chromosome structure, organization, and function; DNA replication and replication origins; Eukaryotic cell cycle regulation. |
| BMSE 220B - The Cytoskeleton |
| (2) STAFF |
| Prerequisites: Graduate standing. |
| Structure and function of the eukaryotic cytoskeleton. Structure assembly and function of microtubules, microfilaments, and intermediate filaments. |
| BMSE 220C - Membrane Dynamics and Cell-Cell Interactions |
| (2) STAFF |
| Prerequisites: MCDB 108A-B-C or Chemistry 142A-B-C; and MCDB 101A. |
| Structure and dynamics of biological membranes and membrane proteins, protein translocation and sorting in the endomembrane system of eukaryotic cells, extracellular matrix protein structure/function, cell-matrix and cell-cell interactions, cell adhesion receptors, transmembrane signaling by cell adhesion receptors. |
| BMSE 221 - Preparation and Evaluation of Research Proposals |
| (1) STAFF |
| Prerequisites: BMB 218A-B or MCDB 218A-B. |
| Instruction in preparation writing, and evaluation of research grant proposals. Students are required to submit a full research proposal (in federal funding agency format) at the end of the course. |
| BMSE 222A - Colloids and Interfaces I |
| (3) STAFF |
| Prerequisites: Consent of instructor. |
| Introduction to the various intermolecular interactions in solution and in colloidal systems: Van der Waals, electrostatic, hydrophobic, solvation, H-bonding. Introduction to colloidal systems: particles, micelles, polymers, etc. Suraces: wetting, contact angles, surface tension, etc. |
| BMSE 223 - Signal Transduction |
| (2) STAFF |
| Prerequisites: Graduate standing. |
| A cell's growth is controlled by positive and negative cues from its surroundings. A discussion of the cell's signaling mechanisms that recognize these cues and initiate and intracellular set of events that generates a response. |
| BMSE 229 - Protein Biochemistry |
| (2) STAFF |
| Prerequisites: Graduate standing. |
| Discussion topics relevant to structure-function relationships in proteins including the chemical reactivity of amino acid side chains, posttranslational modifications, and the covalent and noncovalent interactions of multimeric structures. Case studies involve recent advances in structure-function relationships of mechanoproteins. |
| BMSE 230 - Gene Regulation |
| (2) STAFF |
| Prerequisites: Graduate standing. |
| Mechanisms and regulation of transcription and translation in prokaryotic and eukaryotic organisms and their viruses. |
| BMSE 232 - Bacterial Pathogenesis |
| (3) Mahan |
| MCDB 101A-B. |
| The mechanisms by which bacterial pathogens cause disease. Investigation of the bacterial gene products produced during infection to understand the metabolic, physiological, and genetic factors that contribute to the virulence of bacterial pathogens. |
| BMSE 232L - Bacterial Pathogenesis Laboratory |
| (3) Mahan |
| Prerequisites: BMSE 232 (may be taken concurrently). |
| The latest molecular, biochemical, and genetic techniques available for the identification of microbial gene products that contribute to infection.Study of the regulatory parameters that govern their expression. |
| BMSE 235 - Experimental Strategies in Molecular Genetics |
| (1) STAFF |
| Prerequisites: MCDB 101A-B-C and MCDB 108A-B-C. |
| Discussion of experimental strategies used to purify, analyze, and manipulate nucleic acids, isolate molecular clones from complex genomes, physically map genomes, analyze gene expression, and perform reverse genetics. |
| BMSE 239 - Cellular Microbiology |
| (4) Cotter |
| Prerequisites: Graduate standing. |
| Exploration of the mechanisms by which microbes and their eukaryotic hosts interact at the cellular and molecular levels. Focus is on experimental strategies to investigate these interactions and primary literature is discussed. |
| BMSE 244 - Informational Macro- and Supra-Molecules |
| (2) Jaeger |
| Prerequisites: Consent of instructor. |
| Selected topics at the interface of chemistry and biology; informational molecular coding, molecular machines, self-assembling and self-replicating molecular systems, evolution and selection of molecules with binding and catalytic properties, biopolymer-based materials, special emphasis on cutting-edge technologies. |
| BMSE 246 - Membrane Biochemistry |
| (3) Parsons |
| Prerequisites: Chemistry 142A-B-C or Biology 108A-B-C or equivalent. |
| Introduction to the structures and roles of lipids and their behavior, liposomes, membrane proteins and kinetics, protein sorting, and signal transduction. |
| BMSE 250 - Bionanotechnology |
| (2) Fygenson |
| Background in biochemistry and molecular biology. |
| Introduction to macromolecular assemblies and force generation strategies. Topics may also include but are not limited to: conformations and behavior of protein polymers; nucleic acid superstructures and membranes; structure, motility and mechanism of linear and rotary motor proteins; and macromolecular switches. |
| BMSE 251 - Biopharmaceutical Process Engineering |
| (2) Daugherty |
| Prerequisites: Mathematics 5A or equivalent; background in biochemistry. |
| An introduction to the design bioprocess for large-scale production of biopharmaceuticals. Emphasis is placed upon biopharmaceutical products, protein expression systems, host cell optimization, and reactor selection and design. |
| BMSE 252 - Principles of Bioengineering |
| (2) Mitragotri |
| An overview of various aspects of bioengineering including modeling of physiological functions, biomedical devices, drug delivery, and tissue engineering. |
| BMSE 253 - Analytical Biotechnology |
| (2) Soh |
| Prerequisites: Graduate standing. Effective Date changed to S05 per Grad Div (5/3/05). |
| ME 291A. |
| Develops fundamental understanding behind modern methods of biotechnology. Topics include theoretical treatment of the double layer, electrophoresis, polymerase chain reaction, modern optics, and fluorescence. In addition, case studies of contemporary emerging trends are discussed. |
| BMSE 254 - Drug Design |
| (3) Reich |
| Prerequisites: Chemistry 142A-B-C or Biology 108A-B-C. |
| Rational and structure-based drug design; pharmacogenetics; combinatorial chemistry and screens; mechanism-based drug design; drug metabolism; toxicity; quantitative structure activity relationships; enzyme inhibitors. |
| BMSE 255 - Methods in System Biology |
| (3) Doyle |
| Prerequisites: Prior course work in cellular biology, mathematics; consent of instuctor. |
| Fundamentals of dynamic network organization in biology (genes, metabolites). Emphasis on mathematical approaches to model and analyze complex biophysical network systems. Detailed case studies demonstrating successes of systems biology. Basic biological systems reviewed for nonbiologists. |
| BMSE 257 - Special Topics in Biophysics |
| (1-4) STAFF |
| Course varies from year to year according to the currents of the times. |
| BMSE 259 - Selected Topics in Biological Chemistry |
| (1-4) STAFF |
| Prerequisites: Consent of instructor. |
| Selected topics from bio-organic, biophysical, or biological chemistry. Thecontent of this course will vary. |
| BMSE 260 - Research Progress in Biomolecular Science and Engineering |
| (1) Rothman |
| Prerequisites: Graduate standing. |
| Seminars on research being conducted by the faculty of the BMSE interdisciplinary program. |
| BMSE 262 - Research Progress in Biomolecular Science and Engineering |
| (1) STAFF |
| Research presentations by postdoctoral fellows and advanced Ph.D. students of research progress in the department. |
| BMSE 263 - Research Seminars in Biomolecular Science and Engineering |
| (1) STAFF |
| Research seminars presented by invited speakers on current research topics. |
| BMSE 264 - Literature in Signal Transduction |
| (1) Ballester, Lew |
| Prerequisites: Graduate standing. |
| Critical reading and presentation of the literature on signal transduction mechanisms that control cell growth and differentiation. |
| BMSE 281 - Protein Crystallography |
| (3) Perona |
| Prerequisites: Consent of instructor. |
| Introduction to diffraction techniques. Protein crystal growth and morphology. Data collection and reduction strategies. Approaches for solving the phase problem. Crystallographic refinement, including moleculardynamics. Interpretation of crystal structures. |
| BMSE 290 - Group Studies |
| (2) STAFF |
| Prerequisites: Consent of instructor. |
| Presentation and discussion of current research, to be selected from the following list: A. Biomolecular Materials Synthesis; B. Biomineralization; BP. Bacterial Pathogenesis; CE. C. elegans Development; DN. Developmental Neurobiology; HW. Marine Structural Proteins; PM. Molecular Plant-Microbe Interactions; PR. Protein-Nucleic Acid Interactions; S. Molecular Virology and Interferon Action. |
| BMSE 291 - Research Ethics |
| (1) STAFF |
| Prerequisites: Consent of instructor. |
| Discussion of ethical issues in biochemistry-molecular-biology research. |
| BMSE 293 - Computational Methods in Biochemistry-Molecular Biology |
| (1) STAFF |
| Prerequisites: Graduate standing. |
| Survey of computational methods in molecular biology. Topics include analysis and presentation of data, database searching, quantitative image analysis, and protein homology modeling. Emphaisis is on utilizing accessible software tools that are designed for non-programmers. |
| BMSE 294A - Workshop on Biotechnology Project Management |
| (2) Morse |
| Prerequisites: Consent of instructor. |
| Based on presentations by faculty and invited speakers from the biotechnology and pharmaceutical industries. Discussion topics cover all aspects on biotechnology project management including drug discovery and development, scale up and process development, QC/QA, formulation and delivery, clinical development, and regulatory issues. |
| BMSE 294B - Bioengineering: Career and Development Opportunities at the Interface between Biotechnology and Engineering |
| (2) Morse |
| Prerequisites: Consent of instructor. |
| Based on presentations by experts from the bioengineering industry. Presenters describe their companies' technologies and developments, including biosensors, therapeutics, tissue engineering, quantum dots and advanced instrumentation. Training and educational requirements for different career tracks are discussed. |
| BMSE 592 - Laboratory Research Rotation in Biochemistry |
| (3) STAFF |
| Prerequisites: Enrollment in the BMSE Ph.D. program; open to first year graduate students only. |
| Laboratory rotation project in BMSE faculty laboratories. |
| BMSE 595 - Biochemistry/Molecular Biology Literature Seminar |
| (2) STAFF |
| Prerequisites: Consent of instructor; graduate standing. |
| A critical review of research in selected areas of biochemistry-molecular biology. |
| BMSE 595BG - Bacterial Genetics |
| (2) Low |
| Prerequisites: Consent of instructor. |
| A critical review of research in selected fields of biology. |
| BMSE 595BM - Literature in Biomolecular Materials |
| (2) Reich |
| Review of literature relted to biomolecular materials. |
| BMSE 595EZ - Literature in Enzymes |
| (2) Reich |
| Covers literature in enzymes kinetics and mechanisms. |
| BMSE 595MP - Microbial Pathogenesis |
| (2) Mahan |
| Prerequisites: Consent of instructor. |
| A critical review of research in selected fields of biology. |
| BMSE 596 - Directed Reading and Research |
| (2-12) STAFF |
| Prerequisites: Graduate standing; consent of instructor. |
| Individual tutorial. Instructor is usually the student's major research advisor. Each faculty member has a unique number designation. |
| BMSE 598 - Masters Thesis Research and Preparation |
| (2-12) STAFF |
| Prerequisites: Graduate standing as an M.S. student in the BMB program. |
| Preparation of the thesis and writing of the thesis. |
| BMSE 599 - Ph.D. Dissertation Preparation |
| (2-12) STAFF |
| Prerequisites: Graduate standing as a Ph.D. student and advancement to Doctoral Candidacy. |
| Writing of the Ph.D. dissertation. |