2002-2003 UCSB General Catalog 

Chemistry and Biochemistry
Department of Chemistry and Biochemistry,
Division of Mathematical, Life, and Physical Sciences,
Physical Sciences North 1631;
Telephone (805) 893-5675

Undergraduate e-mail: ugradprog@chem.ucsb.edu
Graduate e-mail: gradprog@chem.ucsb.edu
Website: www.chem.ucsb.edu  (will open in a new browser window)

Department Chair: Stanley M. Parsons


Index:

Faculty

Curtis B. Anderson, Ph.D., UC Los Angeles, Associate Professor (organic chemistry)

Donald H. Aue, Ph.D., Cornell University, Associate Professor (organic chemistry)

Guillermo C. Bazan, Ph.D., Massachusetts Institute of Technology, Professor (organic, materials, organometallic chemistry)

Michael T. Bowers, Ph.D., University of Illinois, Professor (physical chemistry)

Frank L. Brown, Ph.D., Massachussetts Institute of Technology, Assistant Professor (biophysical chemistry)

Paula Yurkanis Bruice, Ph.D., University of Virginia, Senior Lecturer with Security of Employment (bio-organic chemistry)

Steven Buratto, Ph.D., California Institute of Technology, Associate Professor (physical chemistry)

Alison Butler, Ph.D., UC San Diego, Professor (bio-inorganic chemistry)

Anthony Cheetham, Ph.D., Oxford University, Professor (inorganic chemistry/materials)

Timothy J. Deming, Ph.D., UC Berkeley, Associate Professor (organic chemistry)

Mattanjah S. de Vries, Ph.D., University of Amsterdam, Professor (physical chemistry)

Peter C. Ford, Ph.D., Yale University, Professor (inorganic chemistry)

J. Thomas C. Gerig, Ph.D., Brown University, Professor (bio-organic chemistry)

David O. Harris, Ph.D., UC Berkeley, Professor (physical chemistry)

Thomas M. Hooker, Jr., Ph.D., Duke University, Professor (biophysical chemistry)

William C. Kaska, Ph.D., University of Michigan, Professor (inorganic chemistry)

Bernard Kirtman, Ph.D., Harvard University, Professor (theoretical physical chemistry)

Walter Kohn, Ph.D., Harvard University, Adjunct Professor, 1998 Chemistry Nobel Laureate (chemical physics)

Bruce H. Lipshutz, Ph.D., Yale University, Professor (organic chemistry)

R. Daniel Little, Ph.D., University of Wisconsin, Professor (organic chemistry)

Horia I. Metiu, Ph.D., Massachusetts Institute of Technology, Professor (theoretical physical chemistry)

Martin Moskovits, Ph.D., University of Toronto, Professor (physical chemistry)

Stanley M. Parsons, Ph.D., California Institute of Technology, Professor (biological chemistry)

John Perona, Ph.D., Yale University, Associate Professor (biological chemistry)

Thomas R. R. Pettus, Ph.D., University of Rochester, Assistant Professor (organic chemistry)

Kevin W. Plaxco, Ph.D., California Institute of Technology, Assistant Professor (biological chemistry)

Norbert O. Reich, Ph.D., UC San Francisco, Professor (biological chemistry)

Joan-Emma Shea, Ph.D., Massachussetts Institute of Technology, Assistant Professor (biophysical chemistry)

Geoffrey F. Strouse, Ph.D., University of North Carolina, Chapel Hill, Assistant Professor (inorganic chemistry)

Galen Stucky, Ph.D., Iowa State University, Professor (inorganic chemistry)

Petra A. M. Van Koppen, Ph.D., UC Santa Barbara, Lecturer with Security of Employment, General Chemistry Lab coordinator (physical chemistry)

Richard J. Watts, Ph.D., University of Colorado, Professor (inorganic chemistry)

Alec M. Wodtke, Ph.D., UC Berkeley, Professor (physical chemistry)

Emeriti Faculty

Thomas C. Bruice, Ph.D., University of Southern California, Research Professor

Clifford A. Bunton, Ph.D., University College (London), Professor Emeritus (organic chemistry)

John H. Kennedy, Ph.D., Harvard University, Professor Emeritus (inorganic/analytical chemistry)

Richard M. Martin, Ph.D., University of Wisconsin, Professor Emeritus (physical chemistry)

Roger C. Millikan, Ph.D., UC Berkeley, Professor Emeritus (physical chemistry)

Henry W. Offen, Ph.D., UC Los Angeles, Professor Emeritus (physical chemistry)

Ralph G. Pearson, Ph.D., Northwestern University, Professor Emeritus (inorganic chemistry)

Glyn O. Pritchard, Ph.D., Manchester University, Professor Emeritus (physical chemistry)

Bruce Rickborn, Ph.D., UC Los Angeles, Professor Emeritus (organic chemistry)


The department offers programs leading to the B.S. degree in chemistry or biochemistry or the B.A. degree in chemistry. The B.S. degrees are intended for students interested in careers strongly dependent on chemical knowledge. Such careers are found in chemical, biochemical, and materials science research, and quality control in medicine. Graduates may enter the workforce directly or seek the highest levels of career attainment by enrolling in an appropriate graduate or professional school. The requirements of the B.S. degree in chemistry meet American Chemical Society standards for certification with appropriate choices of upper-division electives.

The B.A. degree in chemistry offers flexibility and is intended for students interested in careers having a significant chemical component such as environmental science, law, technical management, K-12 education, and business. Graduates may enter the workforce directly or seek higher levels of career attainment by enrolling in an appropriate professional program.

Entering majors will be assigned an advisor who should be consulted on departmental opportunities and program requirements. Students must submit their programs to the advisor for approval.

Students seeking a degree from the department and who also are interested in pursuing a California Teaching Credential should consult with the credential advisor in the Graduate School of Education soon after enrolling.

Prizes, Honors, Loan Fund

The Willard L. McRary Prize in Chemistry is given to a graduating senior whose work in chemistry reflects the promise of outstanding scientific achievement, such as that which characterized the career of Professor McRary. The B. R. Baker Memorial Fellowship in Chemistry is awarded to graduate students who have given strong indication, by their graduate or undergraduate record, that they will make continued and substantial contributions to the progress of organic, medicinal, or biological chemistry. The Robert H. DeWolfe Teaching Fellowship is awarded to a graduate student in organic chemistry who has demonstrated excellence in undergraduate instruction. The John H. Tokuyama Memorial Scholarship is awarded annually to an organic chemistry graduate student.The Roche Bio-Science Fellowships recognizes outstanding graduate and undergraduate students in organic chemistry.

Distinction in the Major

Students who have achieved a grade-point average of 3.5 or above in their chemistry courses and who submit a written report of their original research carried out under the guidance of a faculty member and approved by one additional member of the faculty shall be designated as having achieved a Distinction in the Major. Students contemplating this option should advise the departmental undergraduate staff advisor of their intention at the beginning of their senior year.

Senior Honors Program

The senior honors program is available to students with outstanding academic records. The program includes carrying out research (through Chemistry 199) in one of the departmental research groups, presenting a seminar describing this work, and preparing a written research report or thesis. Applications to the honors program should be made to the senior advisor, early in the fall quarter of the senior year.


Undergraduate Program

Bachelor of Science-Biochemistry

Preparation for the major. Chemistry 1A-B-C, 1AL or 1AC, 1BL or 1BC, 1CL or 1CC (or 2A-AC, 2B-BC, 2C-CC), 6A-B or 6A and 7B, 109A-B-C; Mathematics 3A-B-C and 5A; Physics 6A-AL-B-BL-C-CL; and labs; MCDB 1A-AL-B; EEMB 2, and either MCDB 1BL or EEMB 2L.

Upper-division major. Forty-six upper-division units, including Chemistry 110L, 112-112L, 113A-B, 125L, 142A-B-C, 173A; six units of core electives from Chemistry 143, 145, 146, 161, 162, 171, 181; five additional units from the above or from Chemistry 111, 115A-B-C, 117, 118, 120, 123, 126 (if 145 not completed), 131A-B-C, 150, 173B, 175, 176.

Students who wish to use Chemistry 196 toward their 5-unit upper-division elective requirement must petition the biochemistry advisor.

Bachelor of Science-Chemistry

Preparation for the major. Chemistry 1A-B-C, 1AL or 1AC, 1BL or 1BC, 1CL or 1CC (or 2A-AC, 2B-BC, 2C-CC), 6A-B-C or 6A, 7B-C, 109A-B-C; Mathematics 3A-B-C, 5A-B; Physics 1, 2, 3, 4, 3L, 4L. A reading knowledge of a foreign language is strongly recommended (German is particularly useful), but not required, for students planning advanced study in science.

Upper-division major. Forty-five upper-division units, including Chemistry 113A-B-C, 116AL-BL-CL, 142A, 150, 173A-B, are required. The 12 elective major units will normally include two physical chemistry courses, one organic or biological chemistry course, and one upper-division laboratory course. Chemistry 101 and 196 will not apply, and Chemistry 199 may be applied only by petition. Courses should be chosen after consultation with the junior or senior advisor.

Note: Transfer students receiving subject credit for Chemistry 150, 150L must complete a minimum of 36 upper-division units in the Department of Chemistry and Biochemistry.

Bachelor of Arts-Chemistry

Preparation for the major. Chemistry 1A-B-C, 1AL or 1AC, 1BL or 1BC, 1CL or 1CC (or 2A-AC-B-BC-C-CC), 6A-B or 6A and 7B; Mathematics 3A-B-C. Physics 1, 2, 3, 4, 3L, 4L, or Physics 6A-B-C, 6AL-BL-CL are required. It is recommended but not required that Mathematics 5A be completed before taking Chemistry 113A-B-C. A reading knowledge of a foreign language is strongly recommended (German is particularly useful), though not required, for students planning advanced study in science.

Upper-division major. Thirty-nine upper-division units, including Chemistry 109A-B-C, 113A-B-C, 116 AL, either 116BL or 116CL, 150, 173A. The final three electives may not include the following: Chemistry101, 196, and 199. One chemistry elective (at least 3 units excluding 101 and 199) is required to complete the major.

Note: Transfer students receiving subject credit for Chemistry 109A-B-C and/or 150, 150L must complete a minimum of 36 upper-division units in the Department of Chemistry and Biochemistry.

Cooperative Program-Chemistry and Chemical Engineering

Chemistry students who are interested in an industrial career are advised to consider a five-year program leading to B.S. degrees in both chemical engineering and chemistry. Students in the cooperative program are required to register simultaneously in the College of Letters and Science and the College of Engineering. They are responsible for completing all degree requirements for each college.

Department of Chemistry and Biochemistry requirements for the program include Chemistry 1A-B-C, 1AL-BL-CL, 6A-B-C, 109A-B-C, 150, 113B-C, 116AL, 116BL, or 116CL, 173A, and two additional upper-division courses in chemistry. Mathematics 3A-B-C, 5A-B-C, Physics 1 (or Mechanical Engineering 10), and Physics 3, 4, 3L, 4L are also required.

Interested students may obtain more information about the program from the Department of Chemistry and Biochemistry or the Department of Chemical Engineering. Final admission to the program is subject to the approval of the dean or provost of each college.

Minor-Chemistry

All courses to be applied to the minor must be completed on a letter-grade basis. This includes both courses offered in chemistry and those offered by other departments and applied to the minor.

Preparation for the minor. No specific courses are required for the minor in chemistry, but students should note that most upper-division chemistry courses include Chemistry 1A-B-C as prerequisite, and many require mathematics courses through 5A as prerequisite.

Upper-division minor. Twenty upper-division units, including at least one course (4 units) in physical chemistry (Chemistry 113A or 113B or 113C); and 16 units of additional upper-division chemistry courses (Chemistry 101,196, and 199 may not apply).

Note: Substitutions and waivers are subject to approval by the chair of the department. Please see "Academic Minors" for special conditions governing minors in the College of Letters and Science.  

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Graduate Program

Admission

The M.S., M.A., or Ph.D. degrees may be obtained in any one of the special fields of analytical, biological, inorganic, organic, materials, physical, or theoretical chemistry. In addition to departmental requirements, candidates for graduate degrees must meet university degree requirements found in the section "Graduate Education at UCSB." In addition to fulfilling the departmental admission requirements, applicants must also meet the university requirements for admission described in the section "Graduate Education at UCSB." Graduate Study in Chemistry, a publication containing admission and degree requirements, is available upon request from the Department of Chemistry and Biochemistry.

Applications are accepted all year long for fall, winter, and spring quarters. However, January 15 is the priority deadline for fall applications and for campuswide fellowship competition.

Master of Science or Master of Arts-Chemistry

The M.S. in chemistry may be attained under Plan 1 (thesis based on research). The M.A. in chemistry may be obtained under Plan 2 (examination). The student must present a literature-based seminar to the department (both plans). The Department of Chemistry and Biochemistry emphasizes graduate work leading to the Ph.D.

Doctor of Philosophy-Chemistry

The Ph.D. degree in chemistry will be awarded upon the successful completion of the following requirements: (1) a core curriculum; (2) two preliminary evaluations; (3) a seminar presentation unrelated to the dissertation research field; (4) the Ph.D. oral qualifying examination for advancement to candidacy; and (5) submission and successful defense of a research dissertation. The main features and time schedule of these requirements are briefly summarized below; a complete document is available in the department.

A six-course curriculum is established with and approved by the divisional academic advisor and normally completed during the first year. Several additional elective courses will be taken during the first and second year. The two preliminary evaluations include written examinations, propositions, and cumulative examinations, depending on the division. Typically, all requirements and the seminar presentation must be completed before the Ph.D. oral qualifying examination. The Ph.D. qualifying oral examination, which focuses on the student's dissertation research field, is usually scheduled for the end of the sixth quarter.

Ph.D. candidates will prepare and defend a dissertation detailing an original work of research in their field of specialization.

Interdepartmental Graduate Program in Biomolecular Science and Engineering

For details see section entry under Biomolecular Science and Engineering.

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Chemistry and Biochemistry Courses

Lower Division

1A. General Chemistry
(3) Staff

Recommended preparation: Chemistry 1AC or 1AL (may be taken concurrently); high-school algebra, chemistry and physics.
Not open for credit to students who have completed Chemistry 2A. Lecture, 3 hours.

Stoichiometry, gas laws and kinetic theory, atomic and molecular structure, the periodic table, nature of solids, liquids and solutions, phase equilibria.

1AC-BC-CC. General Chemistry Cooperative Laboratory
(1-1-1) Van Koppen

Recommended preparation: concurrent enrollment in Chemistry 1A (for Chem 1AC): Chemistry 1B (for Chem 1BC): Chemistry 1C (for Chem 1CC).
Not open for credit to students who have completed Chemistry 1AL-BL-CL or 2AC-BC-CC or 2AL-BL-CL. Lab fee required. Laboratory, 4 hours.

Quantitative and qualitative measurements demonstrating principles and developing laboratory technique. Students work in small groups to develop a unique perspective of the experiment.

1AL. General Chemistry Laboratory
(1) Van Koppen

Recommended preparation: Chemistry 1A (may be taken concurrently).
Not open for credit to students who have completed Chemistry 1AC or 2AC. Lab fee required. Laboratory, 4 hours.

Quantitative measurements demonstrating principles and developing laboratory technique. Inorganic qualitative analysis. Inorganic synthesis.

1B. General Chemistry
(3) Staff

Recommended preparation: Chemistry 1A and, Chemistry 1AC or 1AL; or, Chemistry 2A or 2AC; and, Chemistry 1BC or 1BL (may be taken concurrently); high-school algebra, chemistry and physics.
Not open for credit to students who have completed Chemistry 2B. Lecture, 3 hours.

Thermodynamics (1st and 2nd laws), reaction kinetics, thermochemistry, oxidation and reduction, electrochemistry, chemical equilibrium.

1BL. General Chemistry Laboratory
(1) Van Koppen

Recommended preparation: Chemistry 1A and, 1AC or 1AL; or, Chemistry 2A and 2AC; and, Chemistry 1B (may be taken concurrently).
Not open for credit to students who have completed Chemistry 1BC or 2BC. Lab fee required. Laboratory, 4 hours.

Quantitative measurements demonstrating principles and developing laboratory technique. Inorganic qualitative analysis. Inorganic synthesis.

1C. General Chemistry
(3) Staff

Recommended preparation: Chemistry 1B and, Chemistry 1BC or 1BL; or, Chemistry 2B-BC; and, Chemistry 1CC or 1CL (may be taken concurrently) high-school algebra, chemistry and physics.
Not open for credit to students who have completed Chemistry 2C. Lecture, 3 hours.

Structure and dynamics of elements and their compounds. Aspects of technology and environmental problems.

1CL. General Chemistry Laboratory
(1) Van Koppen

Recommended preparation: Chemistry 1B and, 1BC or 1BL; or, Chemistry 2B-BC; and, Chemistry 1C (may be taken concurrently).
Not open for credit to students who have completed Chemistry 1CC or 2CL. Lab fee required. Laboratory, 4 hours.

Quantitative measurements demonstrating principles and developing laboratory technique. Inorganic qualitative analysis. Inorganic synthesis.

2A. General Chemistry (Honors)
(3) Staff

Recommended preparation: Chemistry 2AC (may be taken concurrently); high-school chemistry or physics, one quarter of calculus (may be taken concurrently).
Not open for credit to students who have completed Chemistry 1A. Lecture, 3 hours.

The sequence of topics will be similar to that in Chemistry 1A. Calculus will be used as needed, at the level of the concurrent Mathematics 3A course.

2AC. General Chemistry Laboratory (Honors)
(1) Staff

Recommended preparation: Chemistry 2A (may be taken concurrently).
Not open for credit to students who have completed Chemistry 1AL or 1AC. Lab fee required. Laboratory, 3 hours.

Quantitative measurements demonstrating principles and developing laboratory technique.

2B. General Chemistry (Honors)
(3) Staff

Recommended preparation: Chemistry 2A and 2AC; or, Chemistry 1A and, Chemistry 1AL or 1AC with a grade of B or better; and, Chemistry 2BC (may be taken concurrently).
Not open for credit to students who have completed Chemistry 1B. Lecture, 3 hours.

Thermodynamics, reaction kinetics, thermochemistry, oxidation and reduction, electrochemistry, chemical equilibrium. Laboratory required.

2BC. General Chemistry Laboratory (Honors)
(1) Staff

Recommended preparation: Chemistry 2A and 2AC; or, Chemistry 1A and, Chemistry 1AC or 1AL with a grade of B or better; and, Chemistry 2B (may be taken concurrently).
Not open for credit to students who have completed Chemistry 1BC or 1BL. Lab fee required. Laboratory, 3 hours.

Laboratory techniques. Thermodynamics, reaction kinetics, thermochemistry, oxidation and reduction, electrochemistry, chemical equilibrium.

2C. General Chemistry (Honors)
(3) Staff

Recommended preparation: Chemistry 2B and 2BC; or, Chemistry 1B and, Chemistry 1BC or 1BL with a grade of B or better; and, Chemistry 2CC (may be taken concurrently).
Not open for credit to students who have completed Chemistry 1C. Lecture, 3 hours.

Structure and dynamics of the elements and their compounds. Aspects of technology and environmental problems. Laboratory required.

2CC. General Chemistry Laboratory (Honors)
(1) Butler, Ford, Strouse

Recommended preparation: Chemistry 2B and 2BC; or, Chemistry 1B and, 1BC or 1BL with a grade of B or better. Lab fee required.
Not open for credit to students who have completed Chemistry 1CC or 1CL. Laboratory, 3 hours.

Laboratory techniques. Structure and dynamics of the elements and their compounds. Aspects of technology and environmental problems.

6A. Laboratory Methods of Organic Chemistry
(2) Staff

Recommended preparation: Chemistry 109A (may be taken concurrently).
Lab fee required.

Distillation, crystallization, extraction, determination of physical properties, organic synthesis, spectroscopy, and instrumental methods in organic chemistry.

6B. Laboratory Methods of Organic Chemistry
(2) Staff

Prerequisite: Chemistry 6A.
Not open for credit to students who have completed Chemistry 7B. Lab fee required.
Recommended preparation: Chemistry 109B (may be taken concurrently).

Distillation, crystallization, extraction, determination of physical properties, organic synthesis, instrumental methods in organic chemistry.

6C. Laboratory Methods of Organic Chemistry
(2) Staff

Prerequisite: Chemistry 6B or 7B.
Not open for credit to students who have completed Chemistry 7C. Lab fee required.
Recommended preparation: Chemistry 109C (may be taken concurrently).

Distillation, crystallization, extraction, determination of physical properties, organic synthesis, instrumental methods in organic chemistry.

7C. Laboratory Methods of Organic Chemistry (Honors)
(2) Staff

Prerequisites: Chemistry 6B or 7B; and, Chemistry 107C (may be taken concurrently).
Not open for credit to students who have completed Chemistry 6C. Lab fee required. Laboratory, 8 hours.

Topics are similar to those in Chemistry 6B-C, but with more flexible laboratory hours and more emphasis on instrumental analysis and spectroscopy for the characterization of organic compounds in conjunction with the Chemistry CS 7 course in the College of Creative Studies.

10. Introduction to Chemical Computing
(2) Staff

Introduction of different computing techniques for computation in UNIX. Applications include: molecular modeling, molecular dynamics, mathematica, Monte Carlo, data analysis, and data mining.

90FS. Freshman Seminar
(2) Staff

Seminar, 2 hours.
Informal discussion limited to 10 students in each section. Each participating faculty member will conduct one section. Subjects will include current technological and environmental problems, and recent advances in basic and applied chemistry.

91. Undergraduate Seminar
(1) Staff

Prerequisite: Chemistry 1A or 1B or 2A or 2B (may be taken concurrently).
May be repeated once for credit. Seminar, 1 hour.

Seminars for undergraduates presented by faculty and/or students.

94. Group Studies in Chemistry
(1) Harris, Buratto

Prerequisite: consent of instructor.
May be repeated for credit to a maximum of 3 units.

Lecture and discussions on special topics.

99. Introduction to Research
(1-3) Staff

Prerequisite: consent of instructor.
May be repeated to a maximum of 6 units. Students are limited to 5 units per quarter and 30 units total in all 98/99/198/199/199DC/199RA courses combined. Tutorial, 3-9 hours.

Directed study, normally experimental, to be arranged with individual faculty members. Course offers exceptional students an opportunity to participate in a research group. Basic techniques and the operation of instruments used in research.

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Upper Division

101. Problems in Environmental Chemistry
(3) Staff

Prerequisites: Chemistry 1A-B; or, Chemistry 2A and 2B. Lecture, 3 hours.
The chemical aspects of energy sources and their impact on the environment; the chemistry of air, water, and soil pollution; sources and methods of control; chemical dynamics in the environment; chemical quality standards and their maintenance.

103A-B. Combinatorial Methods in Chemistry and Chemical Engineering.
(3-3) McFarland

Same course as Chemical Engineering 103A-B.
Recommended preparation: prior coursework in inorganic and organic chemistry.

Basic methodologies of chemical, biological, and materials research and discovery using automated, high-speed synthesis and screening of large numbers of materials. Emphasis on fundamentals necessary for combinatorial design, synthesis, screening, and analysis.

109A-B-C. Organic Chemistry
(4-4-4) Aue, P. Bruice, Lipshutz, Little, Pettus

Prerequisites: Chemistry 1C or 2C (for 109A): Chemistry 109A (for 109B); Chemistry 109B (for 109C).
Not open for credit to students who have completed Chemistry 107A-B, 108, or 130A-B-C.

Structure, reactivity, and synthesis of organic molecules including nomenclature, reaction mechanisms, and stereochemistry. Topics include organometallics, polymers, carbohydrates, amino acids, proteins, nucleic acids, coenzymes, and their mechanisms.

110L. Introductory Biochemistry Laboratory
(4) Staff

Prerequisite: Chemistry 142A (may be taken concurrently).
Recommended preparation: Chemistry 6A-B-C; and, Chemistry 107A-B and 108, or Chemistry 109A-B-C.

Gives students hands-on experience with modern methods of separation, identification, and study of biomolecules and macromolecular structures.

111. Chemical Kinetics
(3) Staff

Prerequisite: consent of instructor. Lecture, 3 hours
The laws and theories governing rates of chemical reactions and reaction mechanisms. Empirical treatment of reaction rates, treatment of data, gas-phase reactions, reactions in solution, catalysis, complex reactions, chain reactions. Collision theory and potential energy surfaces.

112. Biophysical Chemistry
(4) Hooker, Plaxco

Prerequisite: Chemistry 113A.
Thermodynamics, kinetics, and quantum chemistry with special emphasis on biological systems. Some examples of special emphasis: diffusion across and within membranes, diffusion along DNA, phase equilibria and protein folding, spectroscopy (fluorescence, mass spectroscopy, FTIR, NMR), electron transfer and hydrogen bonding.

112L. Biophysical and Bioanalytical Laboratory
(3) Staff

Prerequisite: Chemistry 113A. Lab fee required.
Recommended preparation: Chemistry 113AL.

Introduction to the use of modern biophysical techniques. Fluorescence spectroscopy, mass spectroscopy, FTIR, NMR, diffraction techniques, etc. Emphasis is on quantitative analysis.

113A-B-C. Physical Chemistry
(4-4-4) Bowers, Buratto, Harris, Metiu, Wodtke

Prerequisites: Chemistry 1C or 2C; and, Mathematics 3A-B-C; and, Physics 1 and 2 and 3-3L and 4-4L, or Physics 6A-B-C and 6AL-BL-CL (for Chemistry 113A): Chemistry 113A (for 113B): Chemistry 113B (for 113C).
Recommended preparation: Chemistry 113AL (for Chem 113A - may be taken concurently): Chemistry 116AL and 150 (for Chem 113B - may be taken concurently): Chemistry 113AL and 116BL (for Chem 113C - may be taken concurrently). Lectures, 3 hours; discussions, 1 hour.

A. Chemical thermodynamics: laws of thermodynamics, phase equilibria, chemical equilibria, equations of state.
B. Quantum theory and spectroscopy: introduction to quantum mechanics; symmetry, molecular structure, and spectroscopy.
C. Kinetic theory of gases, chemical kinetics, statistical mechanics, photochemistry.

113AG-BG-CG. Physical Chemistry
(4-4-4) Bowers, Harris, Metiu

Prerequisite: graduate standing.
Not open for credit to students who have taken Chemistry 113A-B-C or the respective part thereof in this institution. Lectures, 3 hours; discussions, 1 hour.

Same description as Chemistry 113A-B-C.

113AL. Physical Chemistry Laboratory
(3) Wodtke

Prerequisite: Chemistry 113A (may be taken concurrently).
Recommended preparation: Chemistry 150 or equivalent. Lecture, 2 hours; laboratory, 8 hours. Lab fee required.

Lecture: instrumental techniques, data analysis, error analysis, instruction in MathematicaR. Laboratory: MathematicaR, a symbolic programming language, is taught in the computer laboratory.

115A-B-C. Fundamentals of Quantum Chemistry
(3-3-3) Kirtman, Wodtke, De Vries

Prerequisites: Mathematics 5A and Chemistry 113A-B-C. Lecture, 3 hours.
A. Introduction to quantum mechanics-postulatory approach; particle in box, on ring, harmonic oscillator; linear operator theory, matrix algebra; hydrogen atom; perturbation theory, variation theory; applications.
B. Molecular orbital theory and valence bond theory; Huckel theory (secular eqn.) applications to conjugated systems. Electronic spectra, and term symbols; introduction to infrared, Raman, and microwave spectroscopy.
C. Introduction to NMR, EPR, group theory; applications.

116AL. Quantitative Analytical and Physical Methods Laboratory
(3) Strouse, Buratto, Bowers, Wodtke

Prerequisites: Chemistry 150; concurrent enrollment in Chemistry 113B (may be taken concurrently). Lecture, 2 hours; Laboratory, 8 hours. Lab fee required.
Principles of analytical chemistry including spectroscopy, classical techniques and separation processes. Quantitative analysis of unknowns. Introduction to instrumental analysis.

116BL. Advanced Physical Chemistry Laboratory
(3) Staff

Prerequisites: Chemistry 150 and 116AL; concurrent enrollment in Chemistry 113C. Lecture, 2 hours; laboratory, 8 hours.
Experiments in thermodynamics, spectroscopy and electrochemistry. Synthesis and study of inorganic complexes. Instrumental techniques such as NMR, fluorescence, Raman and laser flash photolysis is explored. Methods of data and error analysis.

116CL. Inorganic Synthesis and Physical Characterization Laboratory
(3) Staff

Prerequisites: Chemistry 150 and 116BL; concurrent enrollment in Chemistry 173A. Lecture, 2 hours; laboratory, 8 hours.
Synthesis of inorganic and organometallic complexes including techniques for air-sensitive materials. Instrumental characterization and study of synthesized compounds in a research-like setting.

117. Statistical Thermodynamics
(3) Kirtman

Prerequisites: Chemistry 113A-B-C. Lecture, 3 hours.
Fundamentals of statistical thermodynamics, partition functions for ideal gases and crystals, quantum statistics, calculations of thermodynamic properties.

118. Photochemistry and Radiation Chemistry
(3) Buratto

Prerequisites: Chemistry 113A-B-C and 150 and 150L. Lecture, 3 hours.
Interaction of light and matter, reaction paths from electronically excited molecules, flash photolysis, high energy radiation.

120. Polymer Chemistry
(3) Bazan. Deming

Prerequisites: Chemistry 1C or 2C; and, Chemistry 107A-B-C.
Mechanism and kinetics of polymerization: vinyl, condensation, and diene polymers; ionic polymerizations; block and graft polymers; copolymerization; physical chemistry of high polymers; polymer degrations; radiation chemistry of polymer systems.

123. Fundamentals of Environmental Chemistry
(3) Kaska, Watts

Prerequisites: Chemistry 1A-B.
Recommended preparation: Chemistry 1C.

Chemical matters of pollution sources. Principles of analytical monitoring and control of pollution sources. The chemistry of pollutants in the environment. Chemical quality standards and chemical monitoring of the environment.

125L. Laboratory Techniques in Biochemistry
(4) Perona, Reich

Prerequisites: Chemistry 142A-B (may be taken concurrently). Lab fee required.
Protein chemistry (e.g., double labeling radioisotope analysis, two dimensional PAGE, ELISA, HPLC, FPLC, LC-electrospray mass spectrometry, NMR, and EPR), nucleic acid chemistry (e.g., chemical DNA synthesis, DNA sequencing, PCR-based selection), and enzyme kinetics (e.g., inhibition analyses, coupled enzyme assays).

126. Computational Chemistry
(3) Aue

Prerequisites: Chemistry 107A-B. Lecture, 2 hours; laboratory, 4 hours.
Introduction to computational chemistry and molecular modeling. Application of molecular mechanics, quantum mechanics, and computer graphical interfaces to problems in chemistry, biochemistry, drug design and pharmacology.

131A. Advanced Organic Chemistry
(3) Anderson, Aue, Little, Lipshutz, Pettus

Prerequisites: Chemistry 107A-B-C. Lecture, 3 hours.
Physical organic chemistry, mechanism, stereochemistry, structure, and reactivity.

131B. Advanced Organic Chemistry
(3) Aue, Little, Lipshutz, Pettus

Prerequisites: Chemistry 131A. Lecture, 3 hours.
Mechanisms and synthesis in organic chemistry.

131C. Advanced Organic Chemistry
(3) Aue, Little, Lipshutz, Pettus

Prerequisites: Chemistry 131B. Lecture, 3 hours.
Mechanisms and synthesis in organic chemistry.

136. Qualitative Organic Spectroscopic Analysis
(3) Aue, Bazan, Deming, Little, Pettus

Prerequisites: Chemistry 107A-B-C; and Chemistry 6A, and 6B or 7B. Lecture, 2 hours; laboratory, 2 hours.
Identification of unknown organic compounds by analysis of spectra; focus on MS, IR, and NMR.

142A. Chemical Aspects of Biological Systems
(3) Reich, Perona, Parsons

Prerequisites: Chemistry 107A-B-C. Lecture, 3 hours.
Macromolecules of biological importance. A survey of the physical and chemical properties of proteins, nucleic acids, and carbohydrates. Methods of preparation, chemical synthesis, degradation, and characterization of bio-molecules.

142B. Chemical Aspects of Biological Systems
(3) Parsons, Reich, Perona

Prerequisite: Chemistry 142A. Lecture, 3 hours.
Chemical aspects of intermediary metabolism. The chemistry and elementary dynamic properties of enzymes; study of enzyme active sites; characterization of metabolic pathways and methods of examining cellular regulation.

142C. Chemical Aspects of Biological Systems
(3) Parsons, Reich, Perona

Prerequisite: Chemistry 142B. Lecture, 3 hours.
Macromolecular biosynthesis and specialized cellular processes. A survey of nucleic acid and protein biosynthesis, characterization of lipids and membranes; function of membranes in transport, energy transduction, and cellular control; mechanisms of muscle contraction and cell motility.

143. The RNA World
(3) Perona

Prerequisites: Chemistry 142A-B-C; or, MCDB 108A-B-C.
Introduction to RNA structure and thermodynamics. Biological roles of RNA in contemporary organisms. Implications for the origins of life.

145. Computational Biochemistry
(3) Gerig, Perona

Prerequisites: Chemistry 113A-AL and 112; or, Chemistry 113B-C and Chemistry 142A-B-C; or, MCDB 108A-B-C.
Introduction to molecular modeling and molecular dynamics. Discussion of practical considerations of energy minimization, solvent modeling, structure-based drug design. Practical computer graphics experience.

146. Membrane Biochemistry
(3) Parsons, Reich

Prerequisites: Chemistry 142A-B-C; or MCDB 108A-B-C.
Introduction to the structures and roles of lipids and their phase behavior, liposomes, membrane proteins and kinetics, protein sorting, and signal transduction.

147. Astobiology and the Origins of Life
(3) Plaxco

Prerequisite: Chemistry 142A. Lecture, 3 hours.
Discusses the origins and evolution of the solar system and the earth, the origins and evolution of life on earth and the possibilities for life elsewhere in the cosmos all from the perspective of contemporary, terrain biochemistry.

150. Analytical Chemistry
(3) Buratto, Strouse

Prerequisites: Chemistry 1A-B-C or 2A-B-C.
Recommended preparation: Chemistry 116AL (may be taken concurrently). Lecture, 3 hours.

Principles of analytical chemistry including classical techniques, spectrophotochemistry, electroanalytical techniques, and separation processes.

153. Advanced Analytical Techniques
(3) Strouse

Prerequisite: Chemistry 150. Lecture, 2 hours; laboratory, 4 hours. Lab fee required.
Principles of analytical methodology, as in spectroscopy, electronanalysis, and chromatography. Applications to environmental problems, forensic and clinical analysis, and industry. Analysis of solids and surfaces.

156A. Physical Biochemistry
(5) Staff

Prerequisites: Chemistry 113AL, 113C, and 142C. Lecture, 5 hours; discussion, 1 hour.
Isolation and structural analysis of biomolecules, hydrodynamics, spectroscopy, diffraction, scattering.

161. Enzyme Mechanisms
(3) Reich

Prerequisites: Chemistry 142A-B-C; or MCDB 108A-B-C.
Chemistry, structure and function of enzymes; theory, experimental design, and data analysis. Enzyme models and non-classical enzymes.

162. Drug Design
(3) Reich

Prerequisites: Chemistry 142A-B-C; or MCDB 108A-B-C.
Rational drug design. Active site-directed and mechanism-based inhibitors. The use of computers and energy calculations on the design of drugs. Structure based drug design.

171. Bioinorganic Chemistry
(3) Butler

Prerequisite: Chemistry 173A.
Selected topics in bioinorganic chemistry, and metallo-biochemistry. Discussions of metalloproteins and corresponding model compound investigations. Emphasis will be on reactions mechanisms and spectroscopy or properties of metal sites.

173A. Advanced Inorganic Chemistry
(3) Ford, Stucky, Watts

Prerequisites: Chemistry 113A; and, Chemistry 113B-C, or Chemistry 112. Lecture, 3 hours.
Electronic structure of atoms and molecules. Models for bonding in molecules of nontransition and transition elements. Applications of symmetry to bonding, electronic and vibrational spectroscopy. Stereochemistry of transition metal complexes and introduction to organometallics.

173B. Advanced Inorganic Chemistry
(3) Ford, Stucky, Watts

Prerequisite: Chemistry 173A. Lecture, 3 hours.
Structures of ordered crystalline solids, X-ray crystallography. Introduction to solid state chemistry, inorganic materials and chemical catalysis. Bioinorganic chemistry.

175. Physical-Inorganic Chemistry
(3) Ford, Strouse, Watts

Prerequisites: Chemistry 173A-B. Lecture, 3 hours.
Bonding theory, thermodynamics, and structure of inorganic compounds. Applications of physical techniques to the study of inorganic (and organometallic) reactions and their mechanisms.

176. Photochemical and Photophysical Properties of Inorganic and Organometallic Compounds and Materials
(3) Ford, Stucky, Watts

Prerequisite: Chemistry 173A. Lecture, 3 hours.
Discussion of the mechanisms of fundamental physical and chemical events which follow absorption of light by inorganic or organometallic chromophores. Consideration of homogeneous and heterogeneous systems as well as the design and operation of photo-optical and photoelectrical devices.

181. Protein Crystallography
(3) Perona

Prerequisite: consent of instructor.
Introduction to diffraction techniques. Protein crystal growth and morphology. Data collection and reduction strategies. Approaches for solving the phase problem. Crystallographic refinement, including molecular dynamics. Interpretation of crystal structure.

184. Chemical Literature
(2) Huber

Prerequisites: prior enrollment in 3 chemistry courses. Lecture, 2 hours.
Lectures and exercises on the literature and other information resources of use in chemistry.

195. Chemical Instrumentation
(3-5) Staff

Prerequisite: consent of instructor. Discussion, 1 hour; laboratory, 6 to 12 hours.
With guidance from a faculty member students learn advanced laboratory techniques by independent experimental work and weekly consultations with the instructor. This course may be used to satisfy the upper-division laboratory requirement.

196. Special Courses
(1-4) Staff

Prerequisite: consent of instructor. Tutorial, 3-12 hours.
Special courses as a means of meeting special curriculum needs.

197. Senior Thesis Project
(1-4) Staff

Prerequisite: consent of instructor.
Must have a grade-point average in the major of 3.25 or higher.

Academic research supervised by a faculty member, and resulting in a written thesis document.

199. Independent Studies in Chemistry and Biochemistry
(1-5) Staff

Prerequisites: upper-division standing in the major; completion of two upper-division courses in chemistry.
Must have a minimum 3.0 grade-point average for the preceding three quarters. Students are limited to 5 units per quarter and 30 units total in all 98/99/198/199/199DC/199RA courses combined. Not applicable to the B.A. in Chemistry. No more than 12 units of Chemistry 199 may apply toward the B.S. in Chemistry. Tutorial, 1-5 hours.

Coursework shall consist of academic research supervised by a faculty member. This course is not intended for internship credit.

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Graduate Courses

203A-B. Combinatorial Methods in Chemistry and Chemical Engineering
(3-3) McFarland

Prerequisite: consent of instructor.
Same course as Chemical Engineering 203A-B.
Recommended preparation: prior coursework in inorganic and organic chemistry. Lecture, 3 hours.

Foundation and methodologies of chemical, biological, and materials research and discovery using automated, high-speed synthesis and screening. Emphasis on the chemical, biochemical, physical, and mathematical fundamentals necessary for experimental design, synthesis, high-throughput screening and analysis of combinatorial libraries.

211. Chemical Kinetics
(3) Staff

Prerequisite: consent of instructor. Lecture, 3 hours
The laws and theories governing rates of chemical reactions and reaction mechanisms. Empirical treatment of reaction rates, treatment of data, gas-phase reactions, reactions in solution, catalysis, complex reactions, chain reactions. Collision theory and potential energy surfaces.

215A-B. Quantum Mechanics
(3-3) Kirtman, Metiu

Prerequisite: consent of instructor.
Course content changes each year and may be repeated with a different topic (18 units maximum). Lecture, 3 hours.

Selected topics in advanced quantum mechanics. Scattering theory with applications to potential scattering, electron scattering, and chemical reactions. Quantum theory of light and its interaction with matter. Molecular spectroscopy. Electronic structure calculations.

217. Statistical Thermodynamics
(3) Metiu

Prerequisite: consent of the chemistry graduate advisor.
Fundamentals of statistical thermodynamics, partition functions for ideal gases and crystals, quantum statistics, calculations of thermodynamic properties.

218. Photochemistry and Radiation Chemistry
(3) Buratto

Prerequisite: consent of the chemistry graduate advisor.
Interaction of light and matter, reaction paths from electronically excited molecules, flash photolysis, high energy radiation.

219. Selected Topics in Physical Chemistry
(1-4) Staff

Prerequisite: consent of instructor.
Course may be repeated with a different topic (18 units maximum). Lecture, 1 to 4 hours.

Selected topics: orbital symmetry rules for chemical reactions (Pearson); classical theory of light, radiation, and spectroscopy (Metiu); nonlinear optics and nonlinear spectroscopy (Metiu).

221. Transitions Metal Catalyed Polymerization
(3) Deming

Prerequisite: consent of instructor.
Same course as Materials 282. Lecture, 3 hours.

Examination of strategies for controlling molecular weight, chain distribution, sequence, endgroups, and stereochemistry. Discussion of the influence of these variables over structure and properties. Tacticity, control, Ziegler-Natta catalysis, living polymerizations, stereoselective and enantioselective polymerizations, secondary and tertiary structures, polymer assemblies, and biological polymerization.

222A-B-C. Fundamentals of Quantum Chemistry
(3-3-3) Kirtman, Wodtke, Buratto, de Vries

Prerequisites: consent of the graduate advisor; graduate standing.
Not open for credit to students who have completed Chemistry 113A-B-C.

A. Introduction to quantum mechanics-postulatory approach; particle in box, on ring, harmonic oscillator; lineral operator theory, matrix algebra; hydrogen atom; perturbation theory, variation theory; applications.
B. Molecular orbital theory and valence bond theory (secular equ.) applications to conjugated systems, electronic spectra, and term symbols; introduction to infrared Raman, and microwave spectroscopy.
C. Introduction to NMR, EPR, Group Theory; applications.

225. Instrumental Methods in Physical Chemistry
(3) Bowers, Wodtke, de Vries

Prerequisite: consent of instructor.
Advanced undergraduates may enroll by petition to their college office. Lecture, 3 hours.

Fundamentals of basic measurements and advanced research instrumentation are taught. Emphasis is on both practical and conceptual understanding of the methods, suitable for experimental design. Signal electronics, vacuum techniques, molecular beams, lasers, and optics.

230. Modern Instrumental Techniques in Organic Chemistry
(3) Staff

Prerequisite: graduate standing. Lecture, 3 hours.
Practical spectroscopy including infrared and ultraviolet, but with primary emphasis on nuclear magnetic resonance, electron spin resonance, and mass spectroscopy. (Not offered every year.)

231A-B-C. Advanced Organic Chemistry
(3-3-3) Aue, Lipshutz, Little, Bazan, Deming, Pettus

Prerequisite: consent of the chemistry graduate advisor.
Not open for credit to students who have completed Chemistry 226A-B-C.

A. Physical organic chemistry-mechanism, stereochemistry, structure and reactivity.
B and C. Mechanism and synthesis in organic chemistry.

233. Advanced Synthetic Chemistry
(3) Aue, Lipshutz, Little, Pettus

Prerequisite: consent of instructor. Lecture, 3 hours.
A comprehensive discussion of modern synthetic organic methods, including the applications of addition, condensation, substitution, and rearrangement reactions.

236. Molecular Orbital Theory
(3) Aue, Little

Prerequisite: graduate standing. Lecture, 3 hours.
Applications of molecular orbital theory to organic chemistry. (Not offered every year.)

239. Selected Topics in Organic Chemistry
(1-4) Little, Aue, Lipshutz, Bazan, Deming, Pettus

Prerequisite: consent of instructor.
Course may be repeated with a different topic (18 units maximum). Lecture, 3 hours.

Selected topics in organic chemistry. The contents of this course will vary.

242A-B-C. Chemical Aspects of Biological Systems
(3) Parsons, Perona, Plaxco, Reich

Prerequisite: consent of the chemistry graduate advisor.
A. Macromolecules of biological importance. A survey of the physical and chemical properties of proteins, nucleic acids, and carbohydrates. Methods of preparation, chemical synthesis, degradation, and characterization of biomolecules.
B. Chemical aspects of intermediary metabolism. The chemistry and elementary dynamic properties of enzymes; study of enzyme active sites; characterization of metabolic pathways and methods of examining cellular regulation.
C. Macromolecular biosynthesis and specialized cellular processes. A survey of nucleic acid and protein biosynthesis, characterization of lipids and membranes; function of membranes in transport, energy transduction, and cellular control; mechanisms of muscle contraction and cell motility; neurochemistry.

243. The RNA World
(3) Perona

Prerequisites: Chemistry 142A-B-C and MCDB 108A-B-C.
Introduction to RNA structure and thermodynamics. Biological roles of RNA in contemporary organisms. Implications for the origins of life.

245. Computational Biochemistry
(3) Perona, Reich, Gerig

Prerequisites: Chemistry 113A or 112 or 142A-B-C or Chemistry 113A-B-C.
Same course as Biochemistry-Molecular Biology 245.

Introduction to molecular modeling and molecular dynamics. Discussion of practical considerations of energy minimization, solvent modeling, structure-based drug design. Practical computer graphics experience.

246. Membrane Biochemistry
(3) Parsons, Reich

Prerequisites: Chemistry 142A-B-C.
Same course as BMB 246.

Introduction to the structures and roles of lipids and their behavior, lipsomes, membrane proteins and kinetics, protein sorting, and signal transduction.

254A-B. Magnetic Resonance in Biological Systems
(3-3) Gerig

Prerequisite: graduate standing. Lecture, 3 hours.
A discussion of the theory and practice of magnetic resonance methods used in studies of proteins, nucleic acids, and polysaccharides.

256A. Physical Biochemistry
(5) Gerig, Parsons, Perona, Plaxco, Reich

Prerequisites: one year of undergraduate courses in: biochemistry, organic chemistry, and physical chemistry.
Same course as BMB 256A. Lecture, 5 hours; discussion, 1 hour.

Isolation and structural analysis of biomolecules, hydrodynamics, spectroscopy, diffraction, scattering.

256B. Enzyme Kinetics and Mechanisms
(5) Gerig, Parsons, Perona, Plaxco, Reich

Prerequisites: one year of undergraduate courses in each of the following: biochemistry, organic chemistry, physical chemistry.
Same course as BMB 256B. Lecture, 4-5 hours.

Enzyme kinetic and chemical mechanisms. Theory, experimental design, and data analysis. Enzyme models and non-classical enzymes.

258. Mechanisms of Organic and Enzymatic Reactions
(3) Staff

Prerequisite: consent of instructor. Lecture, 3 hours.
Formal presentation of seminars on recent literature dealing with mechanisms of organic and enzymatic reactions accompanied by open discussion of the topics considered.

259. Selected Topics in Biological Chemistry
(1-4) Staff

Prerequisite: consent of instructor.
Same course as BMB 259. Course may be repeated with a different topic (18 units maximum). Lecture, 1 to 4 hours.

Selected topics from bio-organic, biophysical, or biological chemistry. The contents of this course will vary.

261. Enzyme Mechanisms
(3) Parsons

Prerequisites: Chemistry 142A-B-C or MCDB 108A-B-C. Lecture, 3 hours.
Chemistry, structure, and function of enzymes; theory, experimental design, and data analysis. Enzyme models and non-classical enzymes.

262. Drug Design
(3) Reich

Prerequisites: Chemistry 142A-B-C or MCDB 108A-B-C.
Same course as Biochemistry and Molecular Biology 254. Lecture, 3 hours.

Rational and Structure-based drug design; pharmacogentetics; combinatorial chemistry and screens; mechanism based drug design; drug metabolism; toxicity; quantitative structure activity relationships; enzyme inhibitors.

265. Industrial Methods for Polymer Synthesis
(3) Bazan, Strouse, Kaska

Prerequisite: graduate or senior standing. Lecture, 3 hours.
Covers in detail the methods of polymer preparation currently practiced in industry. Special coverage of structure/property relationships in polymers, the design and mechanism of action of action of successful catalysts, and the transformation of basic polymerization reactions into large-scale processes.

266. Photophysics and Device Science of Organic Materials
(3) Bazan, Strouse, Kaska

Prerequisite: graduate or senior standing. Lecture, 3 hours.
Examination of what happens when organic molecules absorb a photon or when they are incorporated within an optoelectronic device. Specific subjects include photoexcitation and relaxation processes, energy transfer, fluorescence depolarization, the design of fluorescence-based biosensors, organic light emitting diodes and field effect transistors.

267. Transition Metal Oxides
(3) Cheetham

Same course as Materials 203. Lecture, 3 hours.
Introduction to transitions metal oxides, ligand field theory, structural basis of magnetism.

268A. Advanced Inorganic Chemistry
(3) Butler, Ford, Stucky, Watts

Prerequisite: consent of the chemistry graduate advisor.
Not open for credit to students who have completed Chemistry 173A, or 272A. Lecture, 3 hours.

Electronic structure of atoms and molecules. Models for bonding in molecules of nontransition and transition elements. Applications of symmetry to bonding, electronic and vibrational spectroscopy. Stereochemistry of transition metal complexes and introduction to organometallics.

268B. Advanced Inorganic Chemistry
(3) Butler, Ford, Stucky, Watts

Prerequisite: consent of the chemistry graduate advisor.
Not open for credit to students who have completed Chemistry 173B, or 272B. Lecture, 3 hours.

Structures of ordered crystalline solids, x-ray crystallography. Introduction to solid state chemistry, inorganic materials and chemical catalysis. Bioinorganic chemistry.

269. Crystallography and Structure Determination
(4) Stucky

Prerequisite: Chemistry 273.
Topics in structure determination: structure factors, integrated intensities, data collection, the phase problem, Patterson synthesis, direct methods, structure refinement, Debye-Waller factors, thermal diffuse scattering and extinction. Rietveld analysis of powder diffraction data. Synchrotron X-rays, neutron diffraction, electron diffraction, non-crystalline materials.

270. Graduate Seminar in Inorganic/Analytical Chemistry
(2) Staff

Prerequisite: graduate standing. Seminar, 2 hours.
Seminars on current research topics in Inorganic/Analytical Chemistry presented by faculty, visiting scholars, and postdoctoral and senior graduate students.

271. Bioinorganic Chemistry
(3) Butler, Ford

Prerequisites: Chemistry 173A-B. Lecture, 3 hours.
Selected topics in bioinorganic chemistry and metallobiochemistry with a major focus on recent developments. Topics will include discussions of metalloproteins and corresponding model compound investigations. Emphasis will be on reaction mechanisms and spectroscopic properties of metal sites.

272. Reaction Mechanisms in Organometallic and Inorganic Chemistry
(3) Butler, Ford

Prerequisites: Chemistry 173A-B. Lecture, 3 hours.
Discussion of chemical reaction mechanisms. Emphasis will be on fundamental reactions of metal compounds such as substitution, addition, elimination, and redox reactions for homogenous catalysis mechanisms and other complex systems.

273. Structural Inorganic Chemistry
(3) Cheetham, Stucky

Prerequisites: Chemistry 173A-B and 175. Lecture, 3 hours.
The use of x-ray and neuron scattering to characterize solid state materials. Subjects include the crystal unit cell, space groups, structure determination and refinement. It is recommended that the student have an elementary introduction to vectors, matrices, and Fourier series.

274. Solid State Inorganic/Materials
(3) Cheetham, Stucky

Prerequisites: Chemistry 173A-B.
Same course as Materials 274. Lecture, 3 hours.

An introductory course describing the synthesis, physical characterization, structure, electronic properties, and uses of solid state materials. (Normally offered in alternate years.)

275. PhysicalInorganic Chemistry
(3) Ford, Watts, Cheetham, Strouse

Prerequisite: consent of the chemistry graduate advisor. Lecture, 3 hours.
Bonding theory, thermodynamics, and structure of inorganic compounds. Applications of physical techniques to the study of inorganic (and organometallic) reactions and their mechanisms.

276. Photochemical and Photophysical Properties of Inorganic and Organometallic Compounds and Materials
(3) Staff

Prerequisites: Chemistry 173A-B. Lecture, 3 hours.
Discussion of the mechanisms of fundamental physical and chemical events which follow absorption of light by inorganic or organometallic chromophores. Consideration of homogeneous and heterogeneous systems as well as the design and operation of photo-optical and photoelectrical devices.

277. Introduction to Inorganic Materials
(3) Cheetham

Prerequisite: Chemistry 274.
Same course as Materials 218.

Structures of inorganic materials: close-packing, linking of simple polyhedra. Factors that control structure: ionic radii, covalency, ligand field effects, metal-metal bonding, electron/atom ratios. Structure-property relationships in e.g. spinels, garnets, perovskites, rutiles, fluorites, zeolites, B-aluminas, graphites, common inorganic glasses.

279. Selected Topics in Inorganic Chemistry
(1-4) Staff

Prerequisite: consent of instructor.
Course may be repeated with a different topic (18 units maximum). Lecture, 3 hours.

This course is designed to reflect recent developments in inorganic chemistry.

284. Chemical Literature
(2) Huber

Prerequisite: consent of the chemistry graduate advisor only. Lecture, 3 hours.
Lectures and exercises on the literature and other information resources of use in chemistry.

290. Seminar in Chemistry and Biochemistry
(2) Staff

Prerequisite: consent of instructor.
May be repeated for credit. Lecture, 1 hour.

Presentation of seminar required of all chemistry graduate students.

291. Special Seminar in Chemistry
(2) Staff

Prerequisite: consent of instructor.
May be repeated for credit. Lecture, 1 hour.

Specialized seminar topics.

293. Faculty Research Seminar
(2) Staff

Prerequisite: consent of instructor. Seminar, 2 hours.
A series of seminars by departmental faculty describing their active research projects.

501A. Techniques of Teaching and Laboratory Class Supervision
(2) Van Koppen

Prerequisite: graduate standing.
S/U grade. Discussion, 1 hour.

An initial 2-3 day workshop is followed by weekly discussion. Topics covered: laboratory organization, supervising experiments, safety, presentations, leading discussions, writing quizzes, advising, and grading. Aimed at new teaching assistants.

594. Special Topics
(1-4) Staff

Variable hours.
Special seminar on research subjects of current interest.

595. Group Studies
(2) Staff

Critical review of research in selected fields. Regular meetings are held in which the student presents for discussion information from the recent chemical literature.

596. Directed Reading and Research
(2-12) Staff

Same course as Biochemistry-Molecular Biology 596CH. No more than half the units necessary for the master's degree may be taken in Chemistry 596. Tutorial, 2-8 hours.
Individual tutorial. Instructor usually the student's major professor. A written proposal for each tutorial must be approved by the department chair. Each faculty member has a unique number designation.

597. Individual Study for Master's Comprehensive Examinations and Ph.D. Examinations
(1-3) Staff

No unit credit allowed toward advanced degree(s). S/U grade. Variable hours.
Instructor should be the student's major professor or chair of the doctoral committee.

598. Master's Thesis Research and Preparation
(1-12) Staff

No unit credit allowed toward advanced degree. S/U grade. Variable hours.
Only for research underlying the thesis, writing the thesis. Instructor should be the chair of the student's thesis committee.

599. Ph.D. Dissertation Research and Preparation
(1-12) Staff

S/U Grade. Variable hours.
Only for research underlying the dissertation, writing the dissertation. Instructor should be the chair of the student's doctoral committee.

Related Courses in Other Departments
EEMB: 126MM, 226MM
MCDB: 108A-B-C, 109L, 123, 140L, 224


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